Uncertainty in data integration systems: automatic generation of probabilistic relationships

This paper proposes a method for the automatic discovery of probabilistic relationships in the environment of data integration systems. Dynamic data integration systems extend the architecture of current data integration systems by modeling uncertainty at their core. Our method is based on probabilistic word sense disambiguation (PWSD), which allows to automatically lexically annotate (i.e. to perform annotation w.r.t. a thesaurus/lexical resource) the schemata of a given set of data sources to be integrated. From the annotated schemata and the relathionships defined in the thesaurus, we derived the probabilistic lexical relationships among schema elements. Lexical relationships are collected in the Probabilistic Common Thesaurus (PCT), as well as structural relationships

A review of tether induced dynamical features

The simplest mathematical model used for the simulation of TSS motion is considered in order to review the dynamics of tethers. This model is discussed. Also reviewed are elasticity effects, perturbation sources, orbit eccentricity and natural frequencies. Tethered systems provide a unique opportunity for skilled measurement activities in space. Some of the experiments envisaged require the measurement of very small mechanical quantities. This implies that the level of dynamical noise on instruments output be low or that system response to excitation, either external or internal, be sufficiently known. In this respect, the first TSS flights will be very useful, but much work will be needed in order to have reliable estimates of structural damping in different future systems

Laparoscopic partial splenectomy.

BACKGROUND: The immunologic function of the spleen and its important role in immune defense has led to splenic-preserving surgery. This study aimed to evaluate whether laparoscopic partial splenectomy is safe. METHODS: Data on consecutive patients presenting with localized benign or malignant disease of the spleen were included in a prospective database. The surgical technique consisted of six steps: patient positioning and trocar placement, mobilization of the spleen, vascular dissection, parenchymal resection, sealing/tamponading of the transected edge, and removal of the specimen. RESULTS: From 1994 to 2005, 38 patients underwent laparoscopic partial splenectomy. The indications included splenomegaly of unknown origin, splenic cysts, benign tumors (hamartoma), and metastasis from ovarian carcinoma and schwannoma. The median operating time was 110 min (range, 65-148 min). The median length of hospital stay was 5 days (range, 4-7 days). There was no postoperative mortality. Postoperative pleural effusion occurred in two patients. There were no reoperations. Three patients required blood transfusions. CONCLUSION: Laparoscopic partial splenectomy is safe for patients with localized benign or malignant disease of the spleen

Schema-agnostic progressive entity resolution

Entity Resolution (ER) is the task of finding entity profiles that correspond to the same real-world entity. Progressive ER aims to efficiently resolve large datasets when limited time and/or computational resources are available. In practice, its goal is to provide the best possible partial solution by approximating the optimal comparison order of the entity profiles. So far, Progressive ER has only been examined in the context of structured (relational) data sources, as the existing methods rely on schema knowledge to save unnecessary comparisons: they restrict their search space to similar entities with the help of schema-based blocking keys (i.e., signatures that represent the entity profiles). As a result, these solutions are not applicable in Big Data integration applications, which involve large and heterogeneous datasets, such as relational and RDF databases, JSON files, Web corpus etc. To cover this gap, we propose a family of schema-agnostic Progressive ER methods, which do not require schema information, thus applying to heterogeneous data sources of any schema variety. First, we introduce two na\uefve schema-agnostic methods, showing that straightforward solutions exhibit a poor performance that does not scale well to large volumes of data. Then, we propose four different advanced methods. Through an extensive experimental evaluation over 7 real-world, established datasets, we show that all the advanced methods outperform to a significant extent both the na\uefve and the state-of-the-art schema-based ones. We also investigate the relative performance of the advanced methods, providing guidelines on the method selection

A multi-layer edge-on single photon counting silicon microstrip detector for innovative techniques in diagnostic radiology

A three-layer detector prototype, obtained by stacking three edge-on single photon counting silicon microstrip detectors, has been developed and widely tested. This was done in the framework of the Synchrotron Radiation for Medical Physics/Frontier Radiology (SYRMEP/FRONTRAD) collaboration activities, whose aim is to improve the quality of mammographic examinations operating both on the source and on the detector side. The active surface of the device has been fully characterized making use of an edge-scanning technique and of a well-collimated laminar synchrotron radiation beam. The obtained data (interlayer distances, channel correspondence, etc.) have then been used to combine information coming from each detector layer, without causing any loss in spatial and contrast resolution of the device. Contrast and spatial resolution have also been separately evaluated for each detector layer. Moreover, imaging techniques (phase contrast, refraction, and scatter imaging), resulting in an increased visibility of low absorbing details, have been implemented, and their effectiveness has been tested on a biological sample. Finally, the possibility of simultaneously acquiring different kind of images with the different detector layers is discussed. This would result in maximizing the information extracted from the sample, while at the same time the high absorption efficiency of the detector device would allow a low dose delivery

Exceptional response to immunotherapy in association with radiotherapy in patient with breast metastasis from urothelial carcinoma: A case report

Most common sites of metastasis of urothelial carcinoma (UC) are lungs, liver, lymph nodes and bone. Pembrolizumab, a humanized monoclonal antibody directed against programmed cell death protein-1 (PD-1), represents an effective second-line therapy for advanced UC. Radiotherapy has been shown to induce a mechanism of immunogenic cell death (ICD) resulting in immune memory and advantageous systemic effects. We present the first case of breast metastasis (BM) from a UC described in literature who had an exceptional response to second-line therapy with pembrolizumab in association with radiotherapy, showing the efficacy of combining immunotherapy and radiotherapy even in patients with atypical metastatic sites

Treadmill Exercise Training Prevents Myocardial Mechanical Dysfunction Induced by Androgenic-Anabolic Steroid Treatment in Rats

Elevated concentrations of testosterone and its synthetic analogs may induce changes in cardiovascular function. However, the effects of the combination of anabolic/androgenic steroid (AAS) treatment and exercise training on systolic and diastolic cardiac function are poorly understood. in the present study, we aimed to investigate the effects of low-dose steroid treatment (stanozolol) on cardiac contractile parameters when this steroid treatment was combined with exercise training in rats and the effects of chronic steroid treatment on the Frank-Starling (length-tension curves) relationship. Male Wistar rats were randomly assigned to one of four groups: U (untrained), US (untrained and treated with stanozolol 5 mg/kg/week), T (trained, 16 m/min/1 h) and TS (trained and treated with stanozolol 5 mg/kg/week). Continuous exercise training was conducted 5 days/week for 8 consecutive weeks. the speed of the treadmill was gradually increased to a final setting of 16 m/min/1 h. Experiments were divided into two independent series: 1) central hemodynamic analysis for mean arterial blood pressure (MAP) and cardiac output (CO) measurements and 2) isolated papillary muscle preparation in Krebs solution. Stanozolol treatment significantly increased the MAP and the heart size in untrained and trained rats (U 113 +/- 2; T 106 +/- 2; US 138 +/- 8 and TS 130 +/- 7 mmHg). Furthermore, stanozolol significantly decreased developed tension and dT/dt (maximal and minimal) in U rats. However, the developed tension was completely restored by training. the Frank/Starling relationship was impaired in rats treated with stanozolol; however, again, training completely restored diastolic function. Taken together, the present data suggest that AAS treatment is able to decrease cardiac performance (systolic and diastolic functions). the combination of stanozolol and physical training improved cardiac performance, including diastolic and systolic functions, independent of changes in central hemodynamic parameters. Therefore, changes in ventricular myocyte calcium transients may play a cardioprotective role.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Judas Tadeu, Dept Post Grad Phys Educ, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, Div Cardiovasc, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, Div Cardiovasc, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, BrazilWeb of Scienc

TA treatment of depression : a hermeneutic single-case efficacy design study - ‘Deborah’

This study is the third of a series of seven, and belongs to the second Italian systematic replication of findings from two previous series (Widdowson 2012a, 2012b, 2012c, 2013; Benelli, 2016a, 2016b, 2016c) that investigated the effectiveness of a manualised transactional analysis treatment for depression through Hermeneutic Single-Case Efficacy Design (HSCED). Major Depression and Subthreshold Depression are often in comorbidity with Anxiety disorders in childhood and adolescence and represent a risk factor for ongoing mental health problems in adulthood. The therapist was a white Italian woman with 15 years of clinical experience and the client, Deborah, was a 15-year old white Italian female adoloscent who attended sixteen sessions of transactional analysis psychotherapy. The conclusion of the judges was that this was a good-outcome case: the depressive and anxious symptomatology clinically and reliably improved over the course of the therapy and these improvements were maintained throughout the duration of the follow-up intervals. Furthermore, the client reported significant change in her post-treatment interview and these changes were directly attributed to the therapy. In this case study, the transactional analysis manualised treatment for depression in adulthood has demonstrated its effectiveness also in treating depressive and anxiety symptoms in adolescence